Meet our Scientific Organizing Committee
The UMDF is pleased to welcome Dr. Douglas C. Wallace, Dr. Deborah Murdock, Dr. Peter McGuire and Dr. Fernando Scaglia as the UMDF Mitochondrial Medicine 2023 Symposium organizing committee. They are putting together an exciting scientific/clinicial program encompassing new discoveries about mitochondrial DNA (mtDNA) structure and function, the role of the mitochondrion in the immune system, the effects on mitochondrial function of viral infection, and novel mitochondrial genetic therapies. Join us as we explore the Mysteries of the Mitochondria this coming June. Family/Patient program details coming soon.
2023 Organizing Committee Chairs
Douglas C. Wallace, PhD, Center for Mitochondrial and Epigenomic Medicine (CMEM) at The Children's Hospital of Philadelphia Research Institute
Deborah Murdock, Children's Hospital of Philadelphia Research Institute
Peter J. McGuire, MS, MD, National Human Genome Research Institute (NHGRI)
Wednesday, June 28, Morning Platform: Mito Inflammation
Topic Title:
Nucleic Acid-mediated Mitonuclear Signaling
Tentative Topic Title:
cGAS-STING-Mitophagy-Neurodegenerative Disease
Tentative Topic Title:
Inflammation & ATP Signaling
Topic Title:
OxPhos Defects, Inflammation and Hypermetabolism
Mitochondrial Medicine Society Wednesday Platform Session
Tentative Topic Title:
Circulating, Cell-free Mitochondrial DNA in Critical Illness
Topic Title:
Are Patients with Mitochondrial Diseases Hypermetabolic?
Tentative Topic Title:
Neurometabolic Regression Risk with Infection in Primary Mitochondrial Disease
Afternoon Session - Topic Title
Current Status of Biomarkers for Mitochondrial Disease
Wednesday, June 28, Afternoon Platform: Mysteries of mtDNA
Topic Title:
Mitochondrial-DNA Encoded Microproteins
Tentative Topic Title:
Mitochondrial-nuclear Coregulation in Health and Disease
Tentative Topic Title:
mtDNA Conformational Regulation
Topic Title:
mtDNA Haplogroup Disease Associations
Thursday, June 29, Morning Platform: Mito/Viruses
Tentative Topic Title:
Mitochondrion and Immune System
Tentative Topic Title:
Viral Exposures in Primary Mitochondrial Disease (PMD) Patients
Tentative Topic Title:
Mitochondria & COVID-19
Topic Title:
Coronaviruses: Intersection of Innate Immune and Integrated Stress Responses
Tentative Topic Title:
Flaviviruses and Integrated Stress Response
Mitochondrial Medicine Society Thursday Platform Session
Tentative Topic Title:
Mitochondrial Disease and the Viral Exposome
Tentative Topic Title:
B Cell Phenotype and Immunoglobulin Replacement Therapy
Tentative Topic Title:
Connections Between the Viral Exposome and Mitochondrial Function
Thursday, June 29, Afternoon Platform: Mito Signaling
Tentative Topic Title:
Mitochondrial and Cellular Metabolism
Tentative Topic Title:
Metabolic Controls
Tentative Topic Title:
MNRR1 Bicompartmental Mito Regulation
Tentative Topic Title:
MAT (Mitochondrial Augmentation Therapy) and MEPAN (Mitochondrial Enoyl CoA Reductase Protein-Associated Neurodegeneration)
Friday, June 30: Combined Sci/Med and Patient/Family Morning Sessions:
State of Mitochondrial Medicine and Clinical Trial Updates
Friday, June 30, Afternoon Session: Mito Genetic Therapy
Tentative Topic Title:
AAV nDNA Gene Therapy
Tentative Topic Title:
mtDNA & Restriction Enzymes
Tentative Topic Title:
mtDNA & Deaminases
Tentative Topic Title:
Nuclear Transplantation
Saturday, July 1, Platform Session: Mito Transfer/Fatty Acid Synthesis
Tentative Topic Title:
Vesicular Transfer
Tentative Topic Title:
Nanotube Transfer
Topic Title:
Discovery of Intracellular Mitochondrial Transfer to Macrophages
Topic Title:
Mitochondrial Transplantation: Clinical Application and Use
Tentative Topic Title:
mtFASII Pathway & Mouse Model
Tentative Topic Title
Mito FASII in OXPHOS Biochemistry
