Save the Date for UMDF Mitochondrial Medicine 2022 - June 8-11, 2022 in Phoenix, AZ

About UMDF Bench-to-Bedside Seminars:

The UMDF Bench-to-Bedside Seminar Series follows in the footsteps of the highly successful Mito Friday Seminar Series launched in 2020. This program addresses a need for increased scientific discussion of important mitochondrial research being conducted around the world. The Bench-to-Bedside (BtB) seminars will take place monthly and typically last one hour.

Recordings from UMDF Bench-to-Bedside webcasts will be made available for a limited time as on-demand or through this web page. Availability of recordings is at the discretion of our presenters.


Researchers and clinicians that would like to suggest a topic or theme are encouraged
to contact UMDF at [email protected]

If you are interested in submitting an abstract for consideration as a future presenter, please utilize our online portal by clicking here.

Upcoming Bench-to-Bedside Seminars

Click Here for Dr. Minear's Slide Deck


Click Here for Dr. Duprecher's Slide Deck


Moderator: Brett Kaufman, PhD


Theme: National Institutes of Health (NIH) and Department of Defense (DOD) Funding Mechanisms in the Mitochondrial Disease Space


Topics & Presenters:

Mitochondrial Disease Research and Funding Opportunities at the NIH and NICHD 

Mollie Minear, PhD, NIH, Health Scientist Administrator-Program Officer


Congressionally Directed Medical Research Programs – Department of Defense

Peer-Reviewed Medical Research Program (PRMRP): Funding Opportunities in Congressionally Directed Topic Areas

Cecelia Dupecher, PhD, DOD, Program Manager


NOTE: Registering for this seminar automatically registers you for March, April and May.

NOTE: Headphones are recommended for optimal listening.

Moderator: Rustum Karanjia, PhD, University of Ottawa Eye Institute, Canada


Theme: Ocular Mitochondrial Disease 


Topics & Presenters:

Development and Translational Steps in Gene Therapy of Leber Hereditary Optic Neuropathy

Jose-Alain Sahel, MD, University of Pittsburgh Medical Center, Pittsburgh, PA


Novel Gene and Drug Therapies for the Treatment of Leber Hereditary Optic Neuropathy

Catherine Tsilfidis, PhD, The Ottawa Hospital Research Institute, Canada


NOTE: Registering for this seminar automatically registers you for April and May.

Moderator: Peter McGuire, MS, MD


Theme: Immune System & Leigh Syndrome


Topics & Presenters:

Immune Mediated Disease Pathogenesis in Leigh Syndrome

Simon Johnson, PhD

University of Washington, Seattle, WA


For May's Bench-to-Bedside, we will share a special UMDF Powerhouse Podcast with special guests, Dr. Robert Naviaux and Dr. Richard Haas, UMDF Mitochondrial Medicine 2022 Co-Chairs. Check it out in May to hear more about symposium sessions, invited speakers, and more.


UMDF Mitochondrial Medicine 2022 is set for June 8-11, 2022 in Phoenix, AZ.



Visit www.umdf.org/mitoscience for program details and to register.


Previous UMDF Bench-to-Bedside Seminars:

Moderator: Brett Kaufman, PhD


Theme: Mitochondrial Dysfunction and Neurodegenerative Disease 


Topics & Presenters:


Mitochondrial Metabolic Shift in ALS

Delfina Larrea, PhD, Columbia University, New York, NY


Markers of Energy and Oxidative Metabolism Alterations in ALS Patient-derived Cells 

Giovanni Manfredi, MD, PhD, Weill Cornell Medicine, New York, NY

Moderator: Brett Kaufman, PhD


Theme: m.3243A>G: From Phenotypes to Omics


Topics & Presenters:


Clinical Characterization and Brain 1H-MRS Imaging Refine the Picture of m.3243A>G Disease

Michio Hirano, MD, Columbia University, New York, NY


Circulating Markers of Reductive Stress in Mitochondrial Disease

Rohit Sharma, MD, PhD, Harvard Medical School, Boston, MA

Moderator: Brett Kaufman, PhD


Theme: National Institutes of Health (NIH) and Department of Defense (DOD) Funding Mechanisms in the Mitochondrial Disease Space


Topics & Presenters:

Mitochondrial Disease Research and Funding Opportunities at the NIH and NICHD 

Mollie Minear, PhD, NIH, Health Scientist Administrator-Program Officer


Congressionally Directed Medical Research Programs – Department of Defense

Peer-Reviewed Medical Research Program (PRMRP): Funding Opportunities in Congressionally Directed Topic Areas

Cecelia Dupecher, PhD, DOD, Program Manager


NOTE: Registering for this seminar automatically registers you for March, April and May.

Tuesday, December 14, 2021

Topics & Presenters

Mitochondrial Metabolic Shift in ALS, Delfina Larrea, PhD, Columbia University, New York, NY

Markers of Energy and Oxidative Metabolism Alterations in ALS Patient-derived Cells, Giovanni Manfredi, MD, PhD, Weill Cornell Medicine, New York, NY


Tuesday, November 17, 2021

Topics & Presenters

Tetracyclines Promote Survival and Fitness in Mitochondrial Disease Models, Pere Puigserver, PhD, Professor of Cell Biology, Harvard University, Boston, Massachusetts, USA

Phenotypic Assays for Developing Mitotherapeutics, Ronald L. Davis, PhD, Professor of Neurology, Scripps Research Institute Florida, Juniper, Florida, US


Tuesday, October 19, 2021

Topic & Presenter

The Viral Exposome in Children with Mitochondrial Disease, Peter J. McGuire MS, MD, National Human Genome Research Institute (NHGRI), Washington, DC


Tuesday, September 21, 2021

Topics & Presenters:

Mitochondrial Transplantation - Basics and Clinical Application, James D. McCully, PhD, Boston Children’s Hospital, Boston, MA


Mitochondrial Transplantation Strategies for the Injured Spinal Cord, Alexander G. Rabchevsky, PhD, University of Kentucky, Lexington, KY


Friday, April 16, 2021

Advancements in Mitochondrial DNA Transfer

Moderator: Brett Kaufman, PhD

Topics & Presenters

New Developments in Mitochondrial DNA Transfer, Michael Teitell, MD, PhD, UCLA

Mitochondrial DNA Intercellular Traveling, Jose Antonio Enriquez, PhD, Spanish National Center for Cardiovascular Research


Thursday, March 18, 2021

Fluid Genomes: mtDNA Dynamics and Respiratory Chain Activity in Blood Leukocytes

Moderator: Peter McGuire, MD

Topics & Presenters:

Cell-type Specific Mitochondrial Phenotypes in Circulating Human Leukocytes, Martin Picard, PhD, Columbia University, New York, NY

Dual Genome 'Omics: the Heteroplasmy Problem, Melissa Walker, MD, PhD, Harvard Medical School, Boston, MA


Thursday, February 18, 2021

Novel Insights from the Mitochondrial Interactome 

Moderator: Brett Kaufman, PhD

Topics & Presenters:

Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis, Martin Ott, PhD, Stockholm University, Stockholm, Sweden

A High-Density Human Mitochondrial Proximity Interaction Network, Hana Antonicka, MSc, PhD, The Neuro & McGill University, Montreal, Quebec, Canada


Friday, January 15, 2021

Novel aspects of mitochondrial NAD+ Biology

Moderator: Brett Kaufman, PhD

Presenters:

Joseph A. Baur, PhD, University of Pennsylvania, Philadelphia, PA

Anu Suomalainen-Wartiovaara, MD, PhD, University of Helsinki, Helsinki, Finland


Friday, December 11, 2020

Nuclear Genome-wide Associations with Mitochondrial Heteroplasmy 

Moderator: Brett Kaufman, PhD

Presenters:

Priyanka Nandakumar, PhD, 23andMe, California 

Neal Sondheimer, MD, PhD, The Hospital for Sick Children, Toronto, ON, Canada


Friday, November 20, 2020

Clinical and Cellular Phenotypes of m.3243A>G

Moderator: Brett Kaufman, PhD

Topics & Presenters:

Clinical Manifestations and Natural History of m.3243A>G, Michio Hirano, MD, Columbia University, New York, NY

m.3243A>G-Induced Mitochondrial Dysfunction Impairs Human Neuronal Development and Reduces Neuronal Network Activity and Synchronicity, Tamas Kozicz, MD, PhD, Mayo Clinic, Rochester, MN


Friday, October 9, 2020


Moderator: Bruce H. Cohen, MD, Akron Children's Hospital, Akron, OH

Topic & Presenters:

Mitochondrial Targets and Defenses in the Time of COVID, Robert K. Naviaux, PhD, University of California San Diego, San Diego, CA and Keshav Singh, PhD, University of Birmingham, Birmingham, AL


Monday, September 21, 2020

Topics & Presenters

Discovery and Implications of Interbacterial Deaminase Toxins, Joseph Mougous, PhD, University of Washington, Seattle, WA

A Bacterial Cytidine Deaminase Toxin Enables CRISPR-Free Mitochondrial Base Editing, David R. Liu, PhD, Harvard University, Cambridge, MA


Friday, August 28, 2020 

UMDF Funded Projects:

  • Investigating intrinsic and extrinsic factors influencing mitochondrial heteroplasmy in mt-tRNA mutation-linked disease - Dr. Kinsley Belle, Postdoctoral Fellow, Stanford University
  • Mechanisms of protein assembly underlying mitochondrial DNA maintenance but altered in early-onset neurodegenerative disorders - Dr. Breann Brown, Assistant Professor, Vanderbilt University
  • Implementation of the CRISPR gene editing technology – Edit Plasmids - toward the curing of mitochondrial diseases caused by mutations in mitochondrial DNA - Dr. Hajime Sakai, CEO, NAPIGEN


Friday, June 19, 2020

Topics & Presenters

Mitochondrial Control of Innate Immune Responses in Disease and Aging, A. Phillip West, PhD, Assistant Professor, Department of Microbial Pathogenesis & Immunology, Texas A&M University

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation During Aging, Ed Chouchani, PhD, Assistant Professor of Cancer Biology and Cell Biology, Dana Farber Cancer Institute and Harvard University


Friday, June 5, 2020

Topics & Presenters

Mouse Models of Mitochondrial DNA Disease, James Stewart, PhD, Research Group Leader, Max Planck Institute for Biology of Ageing

Mitochondrial DNA Heteroplasmy in Disease and Targeted Nuclease-Based Therapeutic Approaches, Carlos Moraes, PhD, Lichtenstein Professor of Neurology, Department of Neurology, University of Miami Miller School of Medicine


Friday, May 22, 2020

Topic & Presenters

Translational and Clinical Perspectives on Mitochondrial DNA Deletions During Normal Aging and POLG Disease, Bruce H. Cohen, MD, Akron Children's Hospital and William Copeland, PhD, NIEHS