Save the Date for UMDF Mitochondrial Medicine 2022 - June 8-11, 2022 in Phoenix, AZ

About UMDF Bench-to-Bedside Seminars:

The UMDF Bench-to-Bedside Seminar Series follows in the footsteps of the highly successful Mito Friday Seminar Series launched in 2020. This program addresses a need for increased scientific discussion of important mitochondrial research being conducted around the world. The Bench-to-Bedside (BtB) seminars will take place monthly and typically last one hour.

Recordings from UMDF Bench-to-Bedside webcasts will be made available for a limited time as on-demand or through this web page. Availability of recordings is at the discretion of our presenters.


Researchers and clinicians that would like to suggest a topic or theme are encouraged
to contact UMDF at [email protected].

If you are interested in submitting an abstract for consideration as a future presenter, please utilize our online portal by clicking here.

Upcoming Bench-to-Bedside Seminars

Moderator: Brett Kaufman, PhD

Topics & Presenters


Mitochondrial Transplantation - Basics and Clinical Application

James D. McCully, PhD, Boston Children’s Hospital, Boston, MA


Mitochondrial Transplantation Strategies

for the Injured Spinal Cord

Alexander G. Rabchevsky, PhD, University of Kentucky, Lexington, KY


Moderator: Brett Kaufman, PhD

Topic & Presenter


The Viral Exposome in Children with Mitochondrial Disease

Peter J. McGuire MS, MD, National Human Genome Research Institute (NHGRI), Washington, DC


Time: 11:00 AM Eastern


Moderator: Brett Kaufman, PhD


Theme: Models of Models of Mitochondrial Diseases and Dysfunction 


Topics & Presenters


Topic Title TBD

Pere Puigserver, PhD, Professor of Cell Biology, Harvard University, Boston, Massachusetts, USA


Topic Title TBD

Ronald L. Davis, PhD, Professor of Neurology, Scripps Research Institute Florida, Juniper, Florida, US

Time: 11:00 AM Eastern


Moderator: TBD


Topics & Presenters:

Coming Soon

Time: 11:00 AM Eastern


Moderator: TBD


Topics & Presenters:

Coming Soon

Time: 11:00 AM Eastern


Moderator: TBD


Topics & Presenters:

Coming Soon

Time: 11:00 AM Eastern


Moderator: TBD


Topics & Presenters:

Coming Soon

Time: 11:00 AM Eastern


Moderator: TBD


Topics & Presenters:

Coming Soon

Previous UMDF Bench-to-Bedside Seminars:

Friday, April 16, 2021

Advancements in Mitochondrial DNA Transfer

Moderator: Brett Kaufman, PhD

Topics & Presenters

New Developments in Mitochondrial DNA Transfer, Michael Teitell, MD, PhD, UCLA

Mitochondrial DNA Intercellular Traveling, Jose Antonio Enriquez, PhD, Spanish National Center for Cardiovascular Research


Thursday, March 18, 2021

Fluid Genomes: mtDNA Dynamics and Respiratory Chain Activity in Blood Leukocytes

Moderator: Peter McGuire, MD

Topics & Presenters:

Cell-type Specific Mitochondrial Phenotypes in Circulating Human Leukocytes, Martin Picard, PhD, Columbia University, New York, NY

Dual Genome 'Omics: the Heteroplasmy Problem, Melissa Walker, MD, PhD, Harvard Medical School, Boston, MA


Thursday, February 18, 2021

Novel Insights from the Mitochondrial Interactome 

Moderator: Brett Kaufman, PhD

Topics & Presenters:

Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis, Martin Ott, PhD, Stockholm University, Stockholm, Sweden

A High-Density Human Mitochondrial Proximity Interaction Network, Hana Antonicka, MSc, PhD, The Neuro & McGill University, Montreal, Quebec, Canada


Friday, January 15, 2021

Novel aspects of mitochondrial NAD+ Biology

Moderator: Brett Kaufman, PhD

Presenters:

Joseph A. Baur, PhD, University of Pennsylvania, Philadelphia, PA

Anu Suomalainen-Wartiovaara, MD, PhD, University of Helsinki, Helsinki, Finland


Friday, December 11, 2020

Nuclear Genome-wide Associations with Mitochondrial Heteroplasmy 

Moderator: Brett Kaufman, PhD

Presenters:

Priyanka Nandakumar, PhD, 23andMe, California 

Neal Sondheimer, MD, PhD, The Hospital for Sick Children, Toronto, ON, Canada


Friday, November 20, 2020

Clinical and Cellular Phenotypes of m.3243A>G

Moderator: Brett Kaufman, PhD

Topics & Presenters:

Clinical Manifestations and Natural History of m.3243A>G, Michio Hirano, MD, Columbia University, New York, NY

m.3243A>G-Induced Mitochondrial Dysfunction Impairs Human Neuronal Development and Reduces Neuronal Network Activity and Synchronicity, Tamas Kozicz, MD, PhD, Mayo Clinic, Rochester, MN


Friday, October 9, 2020


Moderator: Bruce H. Cohen, MD, Akron Children's Hospital, Akron, OH

Topic & Presenters:

Mitochondrial Targets and Defenses in the Time of COVID, Robert K. Naviaux, PhD, University of California San Diego, San Diego, CA and Keshav Singh, PhD, University of Birmingham, Birmingham, AL


Monday, September 21, 2020

Topics & Presenters

Discovery and Implications of Interbacterial Deaminase Toxins, Joseph Mougous, PhD, University of Washington, Seattle, WA

A Bacterial Cytidine Deaminase Toxin Enables CRISPR-Free Mitochondrial Base Editing, David R. Liu, PhD, Harvard University, Cambridge, MA


Friday, August 28, 2020 

UMDF Funded Projects:

  • Investigating intrinsic and extrinsic factors influencing mitochondrial heteroplasmy in mt-tRNA mutation-linked disease - Dr. Kinsley Belle, Postdoctoral Fellow, Stanford University
  • Mechanisms of protein assembly underlying mitochondrial DNA maintenance but altered in early-onset neurodegenerative disorders - Dr. Breann Brown, Assistant Professor, Vanderbilt University
  • Implementation of the CRISPR gene editing technology – Edit Plasmids - toward the curing of mitochondrial diseases caused by mutations in mitochondrial DNA - Dr. Hajime Sakai, CEO, NAPIGEN


Friday, June 19, 2020

Topics & Presenters

Mitochondrial Control of Innate Immune Responses in Disease and Aging, A. Phillip West, PhD, Assistant Professor, Department of Microbial Pathogenesis & Immunology, Texas A&M University

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation During Aging, Ed Chouchani, PhD, Assistant Professor of Cancer Biology and Cell Biology, Dana Farber Cancer Institute and Harvard University


Friday, June 5, 2020

Topics & Presenters

Mouse Models of Mitochondrial DNA Disease, James Stewart, PhD, Research Group Leader, Max Planck Institute for Biology of Ageing

Mitochondrial DNA Heteroplasmy in Disease and Targeted Nuclease-Based Therapeutic Approaches, Carlos Moraes, PhD, Lichtenstein Professor of Neurology, Department of Neurology, University of Miami Miller School of Medicine


Friday, May 22, 2020

Topic & Presenters

Translational and Clinical Perspectives on Mitochondrial DNA Deletions During Normal Aging and POLG Disease, Bruce H. Cohen, MD, Akron Children's Hospital and William Copeland, PhD, NIEHS